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MDMA, which stands for 3,4-methylenedioxymethamphetamine, is commonly referred to as "Molly" in club drug culture. This nickname is often used to refer to the pure crystalline form of the substance, distinguishing it from "Ecstasy," which typically comes in pill form and may contain various other substances or impurities. Molly is known for its euphoric effects, increased energy, and enhanced sensory perception, making it popular among partygoers and festival attendees.

The other substances mentioned—cocaine, heroin, and ketamine—each have distinct pharmacological profiles and effects. Cocaine is a powerful stimulant derived from coca leaves, heroin is an opioid that produces intense euphoria and is associated with high addiction potential, and ketamine is a dissociative anesthetic with different recreational effects. None of these drugs are referred to as MDMA or Molly in the context of club culture, which underscores the significance of the term "Molly" specifically in relation to MDMA.